5 edition of Molecular and Cellular Biology of Insulin-Like Growth Factors and Their Receptors found in the catalog.
January 1, 1990
Written in English
|The Physical Object|
|Number of Pages||511|
The molecular and cellular biology of insulin-like growth factor II Progress in Growth Factor Research, Vol. 4, No. 3 Reciprocal Modulation of Binding of Lysosomal Enzymes and Insulin-Like Growth Factor-II (IGF-II) to the Mannose 6- Phosphate/IGF-II Receptor. Insulin-like growth factor (IGF), formerly called somatomedin, any of several peptide hormones that function primarily to stimulate growth but that also possess some ability to decrease blood glucose levels. IGFs were discovered when investigators began studying the effects of biological substances on cells and tissues outside the body. The name insulin-like growth factor reflects the fact.
Insulin and insulin-like growth factors are widespread throughout the central nervous system. Insulin and IGF-I receptors however, are concentrated in particular brain re- gions and are also found on brain microvessels (). The presence of these receptors suggests that these hormones have significant functions in the brain. This book is geared to every student in biology, pharmacy and medicine who needs to become familiar with receptor mediated signaling. The text starts with explaining some basics in membrane biochemistry, hormone biology and the concept of receptor based signaling as the main form of communication between cells and of cells with the environment. It goes on covering each receptor superfamily in.
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Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors. Authors: Leroith, Derek, Raizada, Mohan K.
During recent years there has been a substantial increase in research related to peptide growth factors, their receptors, and modes of action. With the discovery and characterization of numerous growth factors, it. During recent years there has been a substantial increase in research related to peptide growth factors, their receptors, and modes of action.
With the discovery and characterization of numerous growth factors, it became clear that these growth factors had multiple features in common with classic hormones as well as with oncogenes.
ISBN: OCLC Number: Notes: "Proceedings of a symposium on Molecular and Cellular Aspects of Insulin and Insulin-like Growth Factors I/II: Implications for the Central Nervous System, held January, in Gainesville, Florida"--Title page verso.
Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth. This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation.
Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors. [Derek LeRoith; Mohan K Raizada] Somatomedin Inhibitors -- Section II: Molecular Biology of Insulin-Like Growth Factors -- The Structure and Expression of the Human Insulin-like Growth Factor Genes.
THE insulin-like growth factors (IGFs) and their receptors and binding proteins constitute a family of cellular modulators that play essential roles in the regulation of growth and development.
The IGF ligands include three structurally related peptides: insulin, IGF-I, and by: In the past ten years, molecular biology approaches have provided the structures of multiple components of the IGF system, IGF peptides, receptors, binding proteins, and the mRNAs and genes encoding them.
Progress has been made toward understanding which components of the IGF system are expressed in the nervous system, their cellular localization, and their by: The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 and by a related hormone called IGFIt belongs to the large class of tyrosine kinase receptors.
This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in Aliases: IGF1R, CD, IGFIR, IGFR, JTK13, insulin. PDGF is the major protein growth factor in human serum and is a markedly heat-stable, cationic protein that consists of two related but nonidentical (% amino-acid sequence identity) polypeptide chains designated A and B (also called PDGF-1 and PDGF-2).1,2 PDGF molecules exist as AA and BB homodimers, as well as an AB heterodimer.7 All of the ligands of the PDGF family exhibit similar Cited by: 3.
Molecular aspects of insulin-like growth factors, their binding proteins and receptors. Roberts CT Jr, Leroith D. As we have tried to illustrate in the preceding brief review of some of the current research on the molecular biology of the IGF system, the physiological function of these important and pluripotent molecules will undoubtedly prove Cited by: Insulin like‐growth factors‐I, ‐II and insulin bind to their receptors by activating the PI3K/AKT/mTOR pathway and the Ras/Raf‐1/MEK/ERK signalling casc Nutrient‐sensitive PI3K–AKT–mTOR pathways have a crucial role in regulating the balance between quiescence and proliferation of progenitor cells in many tissues.
The insulin RTK family includes the insulin receptor (INSR) and the insulin-like growth factor-1 receptor (IGF1R). These receptors are heterotetramers consisting of two α and β subunits in an αββα configuration (Figure ). The cysteine-rich extracellular α subunits are linked by disulfide bonds, and each α subunit is.
Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in childhood growth, and has anabolic effects in adults.
IGF-1 is a protein that in humans is encoded by the IGF1 gene. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide s: IGF1, IGF-I, IGF1A, IGFI, MGF, insulin.
Insulin-like growth factor –binding protein-1, also known as pregnancy-associated α 1-protein and placental prot is a major secretory product of decidual cells. It is one of several proteins that bind IGF-1 and IGF-2, affecting the ability of these growth factors to interact with the IGF receptors.
Consequently, the binding. Derek LeRoith is the author of Insulin-like Growth Factors and Cancer ( avg rating, 0 ratings, 0 reviews), Diabetes Mellitus ( avg rating, 0 rating 3/5(1).
Insulin, insulin-like growth factors 1 and 2 (IGF-1 and -2, respectively), and their receptors (IR and IGF-1R) are the key elements of a complex hormonal system that is essential for the development and functioning of humans.
The C and D domains of IGFs (absent in insulin) likely play important roles in the differential binding of IGF-1 and -2 to IGF-1R and to the isoforms of IR (IR-A and IR-B Cited by: 9. The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of both IGF-I and IGF-II.
The IGF-IR is expressed in most transformed cells, where it displays potent. The insulin receptor (IR) 1 and the insulin-like growth factor (IGF) I receptor (IGF-IR) are tetrameric glycoproteins composed of two extracellular α- and two transmembrane β-subunits linked by disulfide bonds.
Each α-subunit, containing the ligand-binding site, is ∼ kDa, whereas each β-subunit, containing the tyrosine kinase domain, is ∼95–97 kDa.
This book is geared to every student in biology, pharmacy and medicine who needs to become familiar with receptor mediated signaling.
The text starts with explaining some basics in membrane biochemistry, hormone biology and the concept of receptor based signaling as the main form of communication between cells and of cells with the environment.
Proteins, called growth factors, are mainly responsible for determining the fate of cells. The actions of growth factors are mediated by their interaction with specific receptors composed of an extracellular ligand-binding portion, a membrane spanning region, and a cytoplasmic : Hardcover.
Cellular and Molecular Biology Program EXPRESSION AND FUNCTION OF INSULIN-LIKE GROWTH FACTOR SIGNALING RECEPTORS IN MAMMARY EPITHELIAL CELL GROWTH A Thesis in Several components of the insulin-like growth factor (IGF) system, the IGF ligands and the IGF-type I receptor (IGF-1R) in particular, regulate both normal and Author: Anne Marie Rowzee.Milk production is dependent on the number of milk-producing cells in the mammary gland at any one time.
Milk production increases following calving in a dairy cow, reaching a peak after 6 to 8 weeks, after which milk yield gradually declines.